Ma laga yaabaa in biomarker-ka cusub ee dhiigga uu kaa caawiyo saadaalinta khatarta Alzheimers?

Daraasad cusub ayaa soo jeedinaysa in astrocytes, oo ah nooca unugyada maskaxda, ay muhiim u yihiin isku xirka amyloid-β iyo marxaladaha hore ee cudurka tau.Karyna Bartashevich/Stocksy

• Astrocytes-ka firfircoon, oo ah nooc ka mid ah unugyada maskaxda, ayaa ka caawin kara saynisyahannada inay fahmaan sababta dadka qaar ee garashada caafimaadka qaba iyo kaydka amyloid-β ee maskaxdooda aysan u yeelanin calaamado kale oo Alzheimers ah, sida borotiinnada tau-ga ah.
• Daraasad lala yeeshay in ka badan 1,000 kaqeybgalayaashu waxay eegeen biomarkers waxayna ogaadeen in amyloid-β ay ku xiran tahay oo kaliya heerarka korodhka tau ee shakhsiyaadka leh calaamadaha falcelinta astrocyte.
• Natiijooyinka waxay soo jeedinayaan in astrocytes ay muhiim u tahay isku xirka amyloid-β ee marxaladaha hore ee pathology tau, taas oo bedeli karta sida aan u qeexno hore ee cudurka Alzheimers.

Isku-ururinta lakabyada amyloid iyo borotiinnada tau ee maskaxda ku jira ayaa muddo dheer loo tixgeliyey sababta koowaad eeCudurka Alzheimers (AD).

Kobcinta maandooriyaha waxay u janjeertay inay diirada saarto beegsiga amyloid iyo tau, iyadoo la dayacay doorka suurtagalka ah ee hababka kale ee maskaxda, sida nidaamka neuroimmune.

Hadda, cilmi-baaris cusub oo laga sameeyay Jaamacadda Pittsburgh School of Medicine ayaa soo jeedinaysa in astrocytes, kuwaas oo ah unugyada maskaxda ee qaabaysan, ay door muhiim ah ka ciyaaraan go'aaminta horumarka Alzheimers.

Astrocytes isha lagu kalsoon yahaywaxay ku badan yihiin unugyada maskaxda.Unugyada kale ee glial-ka ah, unugyada difaaca maskaxda ee deggan maskaxda, astrocytes waxay taageeraan neurons-yada iyaga oo siinaya nafaqo, ogsijiin, iyo ka-hortagga cudurrada.

Markii hore doorka astrocytes ee isgaarsiinta neerfaha waa la iska indhatiray maadaama unugyada glial aysan u dhaqmin koronto sida neurons.Laakiin Jaamacadda Pittsburg daraasadda ayaa caqabad ku ah fikraddan waxayna iftiiminaysaa doorka muhiimka ah ee astrocytes ee caafimaadka maskaxda iyo cudurrada.

Natiijooyinka ayaa dhowaan lagu daabacayDaawada Dabiiciga ah ee lagu kalsoon yahay.

Cilmi-baaris hore ayaa soo jeedinaysa in khalkhalgelinta hababka maskaxda ee ka baxsan culeyska amyloid, sida bararka maskaxda oo kordha, laga yaabo inay door muhiim ah ka ciyaaraan bilawga isku xigxiga dhimashada ee dhimashada neuronal taasoo keenta hoos u dhaca garashada degdega ah ee Alzheimers.

Daraasaddan cusub, cilmi-baarayaashu waxay sameeyeen baaritaanno dhiig oo ku saabsan 1,000 kaqeybgalayaasha saddex daraasadood oo kala duwan oo ku lug leh dadka waaweyn ee garashada caafimaadka qaba iyo kuwa aan lahayn amyloid dhisma.

Waxay falanqeeyeen shaybaarada dhiigga si ay u qiimeeyaan biomarkers fal-celinta falcelinta astrocyte, gaar ahaan borotiinka fibrillary acidic protein (GFAP), oo ay weheliso joogitaanka tau pathological.

Cilmi-baadhayaashu waxay ogaadeen in kaliya kuwa leh labadaba culeyska amyloid iyo calaamadaha dhiigga ee tilmaamaya firfircoonida astrocyte aan caadiga ahayn ama falcelinta ay u badan tahay inay yeeshaan calaamadaha Alzheimers mustaqbalka.