Baykerker-ka cusub ee dhiiga ma ka caawin karaa saadaalin kara halista Alzheimer?

Daraasad cusub ayaa soo jeedisay in astrocytes, nooc ka mid ah unugyada maskaxda, ay muhiim u yihiin isku xirka amyloid-β marxaladaha hore ee tautlogy-ga. Karya Bartshich / Stocksy

• Falanqeedka Astrocytes, nooc ka mid ah unugyada maskaxda, waxay gacan ka geysan kartaa saynisyahanooyinka dadka qaar ee garashada caafimaad qaba iyo abuurka amyloid-ka aan sameynin calaamadaha kale ee cudurka Alzheimer, sida bogagga borotes.
• Daraasad laga sameeyay in ka badan 1,000 kaqeybgalayaal ah ayaa eegay biomarkers waxayna ogaadeen in Amyloid-β oo keliya lala xiriirinayo kororka heerarka tau ee shakhsiyaadka ku yeeshay calaamadaha falcelinta.
• Natiijooyinka ayaa sheegaya in astrocytes ay muhiim u tahay isku xirka amyloid-β marxaladaha hore ee TAU-da qaadidka Tau sicirka, kaasoo wax ka beddeli kara sida aan u qeexno cudurka Alzheimer ee hore.

Ururinta taranka amyloid iyo borotiinnada tau ee maskaxda ee maskaxda ee maskaxda ku jira ayaa muddo dheer loo tixgeliyey sababta koowaad eeCudurka Alzheimers (AD).

Horumarinta daroogada ayaa ku dartay in ay diirada saarto bartilmaameedka amyloid iyo tau, dayacaya doorka suuragalka ah ee habraacyada kale ee maskaxda, sida nidaamka neuroimmune.

Hadda, cilmi baaris cusub oo ka socota Jaamacadda Pittsburgh Dugsiyada dawooyinka ee dawada ayaa soo jeedisay in astrocytes, kuwaas oo ah unugyada maskaxda ee qaabeeya, ay door muhiim ah ka ciyaaraan go'aaminta horumarka Alzheimer.

Isha Astrocytestwaxay ku badan yihiin unugyada maskaxda. Iyadoo ay weheliso unugyada kale ee dhalaalaya, unugyada difaaca maskaxda, astrocytes waxay taageeraan neurons iyagoo siiya nafaqooyin, oksijiin, oksijiin, iyo kahortaga cudurada.

Horey doorka Astrocytes ee isgaarsiinta neuronalte ee isgaarsiinta ayaa la iska indhatiray maadaama unugyada dhalaalaya aysan u qaban koronto sida neurons. Laakiin cilmiga jaamacadda Pittsburg waxay caqabad ku tahay fikradan oo ay iftiiminayso doorka muhiimka ah ee astrocytes ee caafimaadka iyo cudurka.

Natiijooyinka ayaa dhawaan la daabacayDabeecadda Dabiiciga.

Daraasaddii hore waxay muujineysaa carqaladeynta habsamida maskaxda ee ka baxsan culeyska maskaxda, sida in la kordhiyo muhimka ah ee ku dhaca ku-meel-gaarka ah ee dhimashada cudurka maskaxda ee horseedda hoos u dhaca ganaaxyada degdega ah ee Alzheimer.

Daraasaddan cusub, cilmi baadhayaashu waxay sameeyeen baaritaanno dhiig oo ku saabsan 1,000 ka-qaybgalayaal ah seddex daraasadood oo kala duwan oo ku lug leh inay gartaan dadka waaweyn ee dadka waaweyn oo aan lahayn.

Waxay falanqeeyeen saami-tusaalayaashii dhiigga si ay u qiimeeyaan biomarkers of the astrcyte-ka, gaar ahaan gibillary acicillary acid ah (gFAP), oo ay weheliso jiritaanka jiritaanka tau.

Baarayaasha waxay ogaadeen in kaliya kuwa labada culays ku qaatay iyo calaamadaha dhiigga ee muujinaya dhaqdhaqaaqa aan caadiga ahayn ee Astrocyte ama falcelinta ay u badan tahay inay horumariyaan cudurka Alzheimer ee mustaqbalka.