—–Maqaalkan waxa laga soo min guuriyayMedpage Maanta
Ka saarida labada ugxan-sidaha ka hor dhalmo-joojintu waxay la xiriirtaa suurtogalnimada sare ee dhibaatooyinka caafimaad ee joogtada ah iyo hoos u dhaca shaqada jireed ee sanado ka dib, gaar ahaan haweenka qalliinka hore loo sameeyay, cilmi-baaris qaybo ka mid ah ayaa la helay.
Marka la barbar dhigo kooxda da'doodu ka yar tahay 46 jir, kuwaas oo maray premenopausal oophorectomy laba-geesoodka ah (PBO) ee xaalado aan fiicneyn - oo leh ama aan lahayn hysterectomy-si fiican loo sameeyay imtixaan socod lix daqiiqo ah oo lagu bixiyo bukaan-socod labaatan sano ka dib waxayna u badan tahay. inuu yeesho xaalado dabadheeraad ah:
Neefta: ama 1.74 (95% CI 1.03-2.93)
Arthritis: ama 1.64 (95% CI 1.06-2.55)
Aapnea hurdo la'aan ah: ama 2.00 (95% CI 1.23-3.26)
Jab: ama 2.86 (95% CI 1.17-6.98)
"Natiijooyinkani waxay muujinayaan saameynta xun ee muddada dheer ee loophorectomy ee haweenka leh calaamadaha ugxan-sidaha ama aan lahayn calaamadaha ugxan-sidaha kuwaas oo ah celceliska khatarta hidde-socodka ee kansarka ugxan-sidaha," ayaa lagu soo gabagabeeyay cilmi-baarayaasha uu hoggaamiyo Michelle Mielke, MD, PhD, oo ka tirsan Jaamacadda Wake Forest University School of Daawooyinka gudaha Winston-Salem, NC, maqaal ku jira Menopause.Natiijooyinkani waa muhiim marka la tixgelinayo in la maro ugxansidaha (PBO) iyo in kale.
Stephanie Faubion, MD, MBA, oo ah agaasimaha caafimaadka ee Society Menopause, ayaa sheegay in natiijooyinka, kuwaas oo ku tiirsan Mayo Clinic's tubectomy iyo Aging Cohort Study-2 (MOA-2), waxay xaqiijinayaan baahida loo qabo dhakhaatiirta inay beddelaan dhaqamadooda.
"Tani waxay ku dartay suugaanta hadda jirta ee ka saaraysa ugxan-yariyada da'da yar, gaar ahaan da'da 46, waxay la xiriirtaa natiijooyin caafimaad xumo," Faubion ayaa u sheegay MedPage Today."Halkaa marka ay marayso, waxa ay ila tahay in aan u baahanahay oo kaliya in aan tallaabo qaadno.”
Faubion, oo sidoo kale ah maamulaha Xarunta Caafimaadka Haweenka ee Mayo Clinic ee Rochester, Minnesota, laakiin aan ku lug lahayn daraasaddan hadda, ayaa sheegtay in guurka dambe (haweenka da'doodu u dhaxayso 46 iyo 49) sidoo kale "ma aha fikrad wanaagsan,” sida laga soo xigtay daraasadda.Kooxdan, waxaa jiray jaanisyo badan oo arthritis-ka iyo apnea hurdada marka la barbar dhigo asaagooda da'doodu u dhiganto, PBO waxay keentay khatarta sare ee cudurrada sambabada xannibaadda ee joogtada ah ee kooxda oo dhan.
Kooxda PBO, qiyaastii 90 boqolkiiba sidoo kale waxaa lagu sameeyay qalliinka ilmo-galeenka, iyo 6 boqolkiiba waxaa laga saaray ilmo-galeenka ka hor;Kooxda tixraaca ee da'da u dhiganta ee aan marin PBO, 9 boqolkiiba ayaa laga saaray ilmo-galeenka.
Mielke ayaa u sheegay MedPage Today in ka saarida ugxan-sidaha inta lagu jiro qalliinka hysterectomy (qaliinka labaad ee ugu badan ee haweenka) uu yahay caado caadi u ah haweenka, qayb ahaan sababtoo ah waxay tirtiraysaa khatarta kansarka ugxan-sidaha.
"Taariikh ahaan," Mielke ayaa sharraxay, "waxaa la rumeysan yahay in marka ilmo-galeenka la saaro, aysan sii jiri doonin awoodda dib u soo saarista, sidaas darteedna looma baahna in laga saaro ugxan-yari."Si kastaba ha ahaatee, muddo ka dib, cilmi-baarisyo badan oo dheeraad ah ayaa muujisay in ka saarista labada ugxan-sidaha ka hor inta aan la gaarin menopause dabiiciga ah ay keeni karto cawaaqib waqti dheer ama khataro waqti dheer ah oo cuduro kale ah.
Haddii ugxan-sidaha la saaro ka hor dhalmo-joojinta dabiiciga ah, caanuhu waxay yiraahdeen, "waxaa si xooggan loogu talinayaa" in haweenku ku sii jiraan daaweynta estrogen ilaa ay ka gaaraan da'da 50.
Cilmi-baadhayaashu waxay xuseen in daraasadda hadda jirta ay ku jirto qiimeyn jireed oo dhammaystiran oo qof ahaaneed oo lagu sameeyay haweenka leh taariikhda la diiwaangeliyay ee PBO, halka daraasadaha kale ee PBO iyo natiijooyinka caafimaadku ay ugu horreyntii ku tiirsan yihiin ururinta aan tooska ahayn ee natiijooyinka diiwaannada caafimaadka, iyagoo ku guuldareystay inay qabtaan "meelo gaar ah ee shaqada jidhka ama tallaabooyinka kale ee la xidhiidha gabowga."
Faahfaahinta daraasadda
Mielke iyo asxaabtiisuba waxay isticmaaleen xogta Nidaamka Isku xidhka Diiwaanka Caafimaadka ee Mashruuca Cudurka Epidemiology ee Rochester (REP) iyo daraasadda MOA-2, taas oo lagu aqoonsaday haweenka Gobolka Olmsted, Minnesota, kuwaas oo lagu daweeyey PBO xaalado aan fiicneyn intii u dhaxaysay 1988 iyo 2007 oo aan joogin Khatarta sare ee kansarka ugxan-sidaha. Ka-qaybgalayaasha MOA-2 ayaa la barbardhigay koox tixraac ah oo haween ah oo aan helin PBO waxaa lagu lammaaniyay koox tixraac ah oo haween ah oo aan helin PBO.
Laga bilaabo 2018, markii daraasad fool-ka-fool ah la billaabay, badi kuwa ku jira PBO iyo kooxaha tixraaca ayaa weli noolaa (91.6% iyo 93.1%, siday u kala horreeyaan).
Kooxda cilmi-baadhistu waxay shaqaaleysiisey 274 dumar ah oo ku hadla Ingiriisiga MOA-2 kuwaas oo si shakhsi ah ula socday PBO ka dib dhexdhexaad ah 22 sano, oo ay ku jiraan 161 bukaan oo hore u maray nidaamka (kahor da'da 46) (59%) iyo 113 bukaan. kuwaas oo habraaca soo daahay (da'da 46 ilaa 49) (41%).
Ka qaybqaatayaasha waa inay ahaadaan 55 sano jir ama ka weyn isdiiwaan galinta waana laga saaray hadii shaybaalojitu ay muujiso xumaan PBO ama hadii aan lagu arag REP 5tii sano ee la soo dhaafay.Waxay da'doodu ku beegnayd 240 ka qaybgalayaasha kooxda tixraaca kuwaas oo aan lahayn PBO.
Guud ahaan, haweenku waxay lahaayeen da'da dhexe ee 67 sano, waxay ahaayeen 97%-99% caddaan, iyo qiyaastii 60% weligood sigaar cabbin.
Cudurada joogtada ah waxaa lagu qiimeeyay diiwaannada caafimaadka.Marka lagu daro ururada hore loo sheegay, cilmi-baarayaashu ma helin wax ururo ah oo u dhexeeya PBO iyo kansarka, sonkorowga, waallida, hypertension, hyperlipidemia, wadnaha wadnaha, kelyaha, thyroid, ama beerka cudurka, osteoporosis, ama weerar ischemic ku-meel-gaar ah.
Baaritaanka jireed waxaa ku jiray cabbirada xoogga iyo dhaqdhaqaaqa.Marka la barbar dhigo kooxda tixraaca ee da'da u dhiganta, haweenka maray PBO waxay lahaayeen saamiga dufanka tayroodh/pteronavicular sare waxayna si liidata u sameeyeen imtixaankii socodka 6-daqiiqo ah (-14 mitir), halka haweenka hore u maray PBO ay si fiican u qabteen 6-daqiiqo. imtixaanka socodka (-18 mitir).Dumarka kooxda PBO dabadii waxay lahaayeen celceliska boqolkiiba baruurta, cufnaanta baruurta, iyo cufnaanta macdanta laf dhabarta marka la barbar dhigo kooxda tixraaca.
Mielke iyo asxaabtiisuba waxay xuseen in sababta oo ah daraasaddu ay ahayd qaybo kala duwan, sababaha aan la qiyaasi karin, iyo daraasado dhaadheer ayaa lagula talinayaa.Waxa kale oo ay xuseen in haweenkii ka qayb qaatay daraasada laga yaabo in ay ka caafimaad badan yihiin dadka caadiga ah, waxa ayna tilmaameen in cadaanka ay u badan yihiin in ay ka mid tahay caqabadaha daraasadan.
Hongguan waxay daryeelaysaa caafimaadkaaga.
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Haddii ay jiraan baahiyo loo qabo agabka caafimaad, fadlan xor u noqo inaad nala soo xidhiidho.
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Waqtiga boostada: Seb-18-2023